动物模型
Cdh5-cre 转基因小鼠
| 标识符CSTR | CSTR:16397.09.0L01000638 |
|---|---|
| 动物模型中文名称 | Cdh5-cre 转基因小鼠 |
| 动物模型英文名称 | B6.Cg-Tg(Cdh5-cre) |
| 疾病概述 | 血管内皮细胞特异性cre工具小鼠 |
| 动物模型背景信息 | C57BL/6 |
| 动物模型制作方法 | 转基因 |
| 动物模型表型数据 | 通过研究发现，Cdh5-cre 成年小鼠中，所有受检器官的血管和血管内皮细胞以及造血细胞亚群中观察到cre表达。 |
| 动物模型鉴定方法 | Cdh5-cre小鼠主要用来跟flox小鼠杂交，而达到特异性敲除的目的。 |
| 相关文章 | 1.Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235(3):759-67. [PubMed: 16450386] [MGI Ref ID J:106155] 2.Corada M; Nyqvist D; Orsenigo F; Caprini A; Giampietro C; Taketo MM; Iruela-Arispe ML; Adams RH; Dejana E. 2010. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell 18(6):938-49. [PubMed: 20627076] [MGI Ref ID J:163848] 3.Economopoulou M; Langer HF; Celeste A; Orlova VV; Choi EY; Ma M; Vassilopoulos A; Callen E; Deng C; Bassing CH; Boehm M; Nussenzweig A; Chavakis T. 2009. Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med 15(5):553-8. [PubMed: 19377486] [MGI Ref ID J:149487] 4.Genetic Resource Sciences at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 MGI Direct Data Submission :. [MGI Ref ID J:184578] Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887] |
| 保种方式 | 冷冻 |
| 模型来源 | |
| 合作方式 | 仅限合作研究 |
| 相关资料下载 | |
| 备注 |
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