动物模型
ACTA1-cre 转基因小鼠（肌肉组织特异）
| 标识符CSTR | CSTR:16397.09.0L01000637 |
|---|---|
| 动物模型中文名称 | ACTA1-cre 转基因小鼠（肌肉组织特异） |
| 动物模型英文名称 | B6.Cg-Tg(ACTA1-cre) |
| 疾病概述 | 肌肉组织特异cre工具小鼠 |
| 动物模型背景信息 | C57BL/6 |
| 动物模型制作方法 | 转基因 |
| 动物模型表型数据 | ACTA1主要成年人横纹肌纤维和胚胎横纹肌细胞的体节和心脏表达。 |
| 动物模型鉴定方法 | ACTA1-cre主要用来跟flox小鼠杂交，而达到特异性敲除的目的。 |
| 相关文章 | 1.Miniou P; Tiziano D; Frugier T; Roblot N; Le Meur M; Melki J. 1999. Gene targeting restricted to mouse striated muscle lineage. Nucleic Acids Res 27(19):e27. [PubMed: 10481039] [MGI Ref ID J:67906] 2.Agrawal PB; Joshi M; Savic T; Chen Z; Beggs AH. 2012. Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet :. [PubMed: 22343409] [MGI Ref ID J:182571] 3.Buj-Bello A; Laugel V; Messaddeq N; Zahreddine H; Laporte J; Pellissier JF; Mandel JL. 2002. The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice. Proc Natl Acad Sci U S A 99(23):15060-5. [PubMed: 12391329] [MGI Ref ID J:81791] Chambon C; Duteil D; Vignaud A; Ferry A; Messaddeq N; Malivindi R; Kato S; Chambon P; Metzger D. 2010. Myocytic androgen receptor controls the strength but not the mass of limb muscles. Proc Natl Acad Sci U S A 107(32):14327-32. [PubMed: 20660752] [MGI Ref ID J:163603] 4.Charvet C; Houbron C; Parlakian A; Giordani J; Lahoute C; Bertrand A; Sotiropoulos A; Renou L; Schmitt A; Melki J; Li Z; Daegelen D; Tuil D. 2006. New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways. Mol Cell Biol 26(17):6664-74. [PubMed: 16914747] [MGI Ref ID J:112113] |
| 保种方式 | 冷冻 |
| 模型来源 | |
| 合作方式 | 仅限合作研究 |
| 相关资料下载 | |
| 备注 |
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